Kleenex Anti-Viral Tissues kill 99.9% of cold and flu viruses, helping you to take care of you and your family during cold and flu season. Made with 3 soft plies, including a moisture-activated middle layer that kills 99.9% of cold and flu viruses in the tissue within 15 minutes. Virucidal against: Rhinoviruses Type 1A and 2 (Rhinoviruses are the leading cause of the common cold), Influenza A and Influenza B (causes of the flu), Respiratory Syncytial Virus (RSV the leading cause of lower respiratory infection in children).