Mississipi Medicine by D.S. & Durga: A Bridge between the Sacred and the Profane Introduction: Mississipi Medicine is one of the most enigmatic and profound fragrances in the D.S. & Durga collection. This perfume is a celebration of the spiritual and medical traditions of the American South, particularly those connected to the Mississippi River. It is a liquid work of art that explores the boundaries between the sacred and the profane, offering a complex and fascinating portrait of a rich and varied culture.